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Home > Drugs > Miscellaneous metabolic agents > Pyrukynd
Miscellaneous metabolic agents

Pyrukynd

https://themeditary.com/drug/pyrukynd-5432.html
Medically Reviewed by Judith Stewart, BPharm TheMediTary.Com | Reviewed: Aug 12, 2023  Additional Content by TheMediTary.Com

Generic name: mitapivat

Drug class: Miscellaneous metabolic agents

Dosage form: tablets, for oral use

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Pyrukynd taper pack, Mitapivat

Contents
Uses Warnings Before Taking Dosage Side effects Interactions
  • Pyrukynd (Mitapivat)-M5-5 mg-Blue-Round Pyrukynd 5 mg (M5)
  • Pyrukynd (Mitapivat)-M20-20 mg-Blue-Round Pyrukynd 20 mg (M20)
  • View all images

What is Pyrukynd?

Pyrukynd is a prescription medicine used to treat low red blood cell counts caused by the early breakdown of red blood cells (hemolytic anemia) in adults with pyruvate kinase deficiency (PK Deficiency).

It is not known if Pyrukynd is safe and effective in children.

How should I take Pyrukynd

  • Take Pyrukynd exactly as your healthcare provider tells you to take it.
  • Take the Pyrukynd tablets with or without food.
  • Swallow the tablets whole. Do not split, chew, crush, or dissolve the tablets.
  • Do not change your dose or stop treatment without talking to your healthcare provider. Your healthcare provider will give you instructions for stopping Pyrukynd. See Pyrukynd side effects.
  • If you miss a dose by 4 hours or less, take your dose as soon as possible. If more than 4 hours have passed since your regularly scheduled dose, wait for the next dose. Return to your normal schedule at the next dose.

Dosing information

Usual Adult Dose for Pyruvate Kinase Deficiency

- Starting dosage: 5 mg orally twice daily with or without food. See table below for dose titration and taper schedule.

- Use: treatment of hemolytic anemia in adults with pyruvate kinase (PK) deficiency

Detailed Pyrukynd dosage information
Duration
Dosage
Week 1 through Week 4 5 mg twice daily
Week 5 through Week 8

If Hb is below normal range or patient has required a transfusion within the last 8 weeks:

  • Increase to 20 mg twice daily and maintain for 4 weeks.

If Hb is within normal range and patient has not required a transfusion within the last 8 weeks:

  • Maintain 5 mg twice daily.
Week 9 through Week 12

If Hb is below normal range or patient has required a transfusion within the last 8 weeks:

  • Increase to 50 mg twice daily and maintain thereafter.

If Hb is within normal range and patient has not required a transfusion within the last 8 weeks:

  • Maintain current dose (5 mg twice daily or 20 mg twice daily).
Maintenance If Hb decreases, consider up-titration to the maximum of 50 mg twice daily as per the above schedule.
Pyrukynd Dosage information (more detail)

Before Taking

Before you start treatment, tell your healthcare provider about all your medical conditions, including if you:

  • have liver problems.
  • are pregnant or plan to become pregnant. It is not known if Pyrukynd will harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think that you are pregnant during treatment.
  • are breastfeeding or plan to breastfeed. It is not known if Pyrukynd passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment.
Pyrukynd pregnancy and breastfeeding warnings (more detail)

Pyrukynd side effects

Pyrukynd may cause serious side effects, including:

  • Rapid breakdown of red blood cells (acute hemolysis) has happened after suddenly interrupting or stopping treatment. You should not suddenly stop taking Pyrukynd. If you have to stop your treatment, your healthcare provider should monitor you closely. Tell your healthcare provider right away if you develop any signs or symptoms of breakdown of red blood cells including:
    • yellowing of the skin or the whites of your eyes (jaundice)
    • dark colored urine
    • dizziness
    • confusion
    • feeling tired
    • shortness of breath

The most common side effects include:

  • decrease in reproductive hormone (estrone) in men
  • increased salt from uric acid (urate) blood test
  • decrease in reproductive hormone (estradiol) in men
  • joint pain (arthralgia)
  • back pain

These are not all of the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Pyrukynd Side Effects

What other drugs will affect Pyrukynd?

Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Pyrukynd and certain other medicines may affect each other causing side effects. Pyrukynd may affect the way other medicines work, and other medicines may affect how Pyrukynd works.

Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.

More about Pyrukynd (Mitapivat)

Dosage information
Pyrukynd Side Effects
During pregnancy
Pyrukynd Prescribing Information
Drug images
Side effects
Drug class: Miscellaneous metabolic agents
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Contents
Uses Warnings Before Taking Dosage Side effects Interactions
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