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Home > Drugs > Glofitamab (monograph) > Glofitamab (monograph) Side Effects
Drugs

Glofitamab Side Effects

Applies to glofitamab: intravenous solution.

Intravenous route (Solution)

Warning: Cytokine Release SyndromeCytokine Release Syndrome (CRS), including serious or fatal reactions, can occur in patients receiving glofitamab-gxbm. Premedicate before each dose, and initiate treatment with the glofitamab-gxbm step-up dosing schedule to reduce the risk of CRS. Withhold glofitamab-gxbm until CRS resolves or permanently discontinue based on severity.

Serious side effects of Glofitamab

Along with its needed effects, glofitamab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking glofitamab:

More common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • burning, numbness, tingling, or painful sensations
  • chest pain
  • cough
  • difficulty in moving
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • headache
  • joint or bone pain
  • muscle cramps, pains, or stiffness
  • pain or swelling at the site of the tumor
  • rapid or irregular heartbeat
  • rapid weight gain
  • sensation of spinning
  • swollen joints
  • tender or swollen lymph nodes
  • tingling of the hands or feet
  • trembling and shaking of hands
  • trouble breathing
  • unsteadiness or awkwardness
  • unusual weight gain or loss
  • weakness
  • weakness in arms, hands, legs, or feet

Less common

  • Black, tarry stools
  • chest tightness
  • confusion as to time, place, or person
  • fever or chills
  • hallucinations
  • holding false beliefs that cannot be changed by fact
  • lower back or side pain
  • mental depression or anxiety
  • nightmares or unusually vivid dreams
  • painful or difficult urination
  • pale skin
  • sleepiness or unusual drowsiness
  • sneezing
  • sore throat
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual excitement, nervousness, or restlessness
  • unusual tiredness or weakness

Other side effects of Glofitamab

Some side effects of glofitamab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • blistering, crusting, irritation, itching, or reddening of the skin
  • constipation
  • cracked, dry, or scaly skin
  • diarrhea
  • neck pain
  • pain in the arms or legs
  • stomach pain
  • swelling

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