Note: This document contains side effect information about ibuprofen / pseudoephedrine. Some dosage forms listed on this page may not apply to the brand name Advil Cold and Sinus.
Applies to ibuprofen / pseudoephedrine: oral capsule liquid filled, oral tablet.
Serious side effects
Along with its needed effects, ibuprofen/pseudoephedrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking ibuprofen / pseudoephedrine:
Incidence not known
- Bloody or black, tarry stools
- chest pain or tightness
- confusion
- constipation
- cough
- decrease urine output
- diarrhea
- difficulty in speaking
- difficulty swallowing
- dilated neck veins
- dizziness
- double vision
- fast heartbeat
- headache
- heartburn
- hives, itching, skin rash
- inability to speak
- inability to move the arms, legs, or facial muscles
- indigestion
- irregular breathing
- nausea
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- severe stomach pain, cramping, or burning
- swelling of the face, fingers, feet, or lower legs
- trouble breathing
- unusual tiredness or weakness
- vomiting of blood or material that looks like coffee grounds
- weight gain
Other side effects
Some side effects of ibuprofen / pseudoephedrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- Dizziness
- nervousness
- trouble sleeping
For Healthcare Professionals
Applies to ibuprofen / pseudoephedrine: oral capsule, oral suspension, oral tablet.
Cardiovascular
Frequency not reported: Heart attack, heart failure, stroke[Ref]
Hypersensitivity
Frequency not reported: Severe allergic reaction (hives, facial swelling, asthma, shock, skin reddening, rash, blisters)[Ref]
Gastrointestinal
Frequency not reported: Stomach bleeding, stomach upset[Ref]
