By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo

TheMediTary.Com

Medical Information, Documents, News - TheMediTary.Com

  • Home
  • News
  • Drugs
  • Drugs A-Z
  • Medical Answers
  • About Us
  • Contact
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo
Search Drugs
  • Drugs
    • Latest Drugs
    • Drugs A-Z
    • Medical Answers
  • News
    • FDA Alerts
    • Medical News
    • Health
    • Consumer Updates
    • Children's Health
  • More TheMediTary.Com
    • About Us
    • Contact
Follow US
Home > Drugs > Potassium-sparing diuretics > Amiloride > Amiloride Side Effects
Potassium-sparing diuretics

Amiloride Side Effects

Applies to amiloride: oral tablet.

Warning

Oral route (Tablet)

Amiloride may cause hyperkalemia, which if uncorrected, is potentially fatal. Hyperkalemia occurs commonly (about 10%) when amiloride is used without a kaliuretic diuretic. This incidence is greater in patients with renal impairment, diabetes mellitus (with or without recognized renal insufficiency), and in the elderly. Monitor serum potassium levels carefully in any patient receiving amiloride.

Serious side effects of Amiloride

Along with its needed effects, amiloride may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amiloride:

More common

  • Abdominal pain
  • confusion
  • difficulty with breathing
  • irregular heartbeat
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • shortness of breath
  • weakness or heaviness of the legs

Less common

  • Agitation
  • back pain
  • blurred vision
  • coma
  • dizziness
  • drowsiness
  • fever
  • hallucinations (seeing things that aren't there)
  • headache
  • irritability
  • labored breathing
  • mood or mental changes
  • seizures (convulsions)
  • stiff neck
  • tightness in the chest
  • unusual tiredness or weakness
  • vomiting
  • wheezing

Rare

  • Arm or jaw pain
  • bloody or black, tarry stools
  • burning while urinating
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in vision
  • chest pain, discomfort, or heaviness
  • chills
  • clay-colored stools
  • cold sweats
  • constipation
  • dark urine
  • difficult or painful urination
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • fainting
  • fast, pounding, racing, or slow heartbeat or pulse
  • itching
  • light-colored stools
  • loss of appetite
  • loss of vision
  • rash
  • shakiness in the legs, arms, hands, or feet
  • stomach pain, severe
  • sweating
  • trembling or shaking of the hands or feet
  • unpleasant breath odor
  • vomiting of blood or material that looks like coffee grounds
  • yellow eyes or skin

Incidence not known

  • Continuing stomach pain
  • cough
  • lower back or side pain
  • pale skin
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen or painful glands
  • unusual bleeding or bruising

Get emergency help immediately if any of the following symptoms of overdose occur while taking amiloride:

Symptoms of overdose

  • Decreased urination
  • dry mouth
  • increase in heart rate
  • lightheadedness
  • muscle cramps or pain
  • pain or weakness in the hands or feet
  • rapid breathing
  • sunken eyes
  • thirst
  • wrinkled skin

Other side effects of Amiloride

Some side effects of amiloride may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • weight loss

Less common

  • Changes in appetite
  • decreased interest in sexual intercourse
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance

Rare

  • Acid or sour stomach
  • belching
  • continuing ringing or buzzing or other unexplained noise in the ears
  • discouragement
  • disturbed color perception
  • double vision
  • excess air or gas in the stomach or intestines
  • feeling of constant movement of self or surroundings
  • feeling sad or empty
  • frequent urination
  • full or bloated feeling
  • hair loss or thinning of hair
  • hearing loss
  • increased need to urinate
  • increased volume of pale, dilute urine
  • indigestion
  • joint pain
  • leg ache or pain
  • loss of interest or pleasure
  • neck or shoulder ache
  • night blindness
  • overbright appearance of lights
  • pain in the chest below the breastbone
  • passing of gas
  • passing urine more often
  • pressure in the stomach
  • seeing halos around lights
  • sensation of spinning
  • sleepiness or unusual drowsiness
  • sleeplessness
  • stomach fullness, discomfort, or upset
  • stuffy nose
  • swelling of abdominal or stomach area
  • swelling of the breasts or breast soreness in both females and males
  • trouble concentrating
  • trouble sleeping
  • tunnel vision
  • unable to sleep

For Healthcare Professionals

Applies to amiloride: compounding powder, oral tablet.

Metabolic

Cases of severe hyponatremia have been reported during hydrochlorothiazide-amiloride therapy. In 3 cases, the patients subsequently did well with hydrochlorothiazide and potassium supplementation, suggesting a significant role for amiloride in the development of their hyponatremia.

Significantly elevated serum uric acid, cholesterol, and triglyceride levels have been associated with combination hydrochlorothiazide-amiloride therapy. These metabolic abnormalities may not be due to amiloride since they are reported during hydrochlorothiazide monotherapy.

Amiloride is known to cause significant elevations in serum aldosterone, renin, and angiotensin II levels.[Ref]

Metabolic side effects are the most common. Amiloride may cause hyperkalemia in up to 10% of patients, although the risk is decreased to about 1% to 2% when thiazide or loop diuretics are coadministered. Patients with diabetes or who are on other potassium-sparing therapy, ACE inhibitors, or potassium supplementation are predisposed to amiloride-induced hyperkalemia.[Ref]

Renal

Renal side effects including renal insufficiency is unusual after amiloride monotherapy because it is only a weak diuretic.[Ref]

Gastrointestinal

Gastrointestinal complaints of diarrhea, nausea, constipation, anorexia, and general abdominal pain occur less than 5% of patients.[Ref]

Nervous system

Nervous system side effects occur in less than 3% of patients, and include headache, weakness, and fatigue. Encephalopathy may be induced by amiloride-associated metabolic changes in some patients with severe liver disease.[Ref]

Cardiovascular

Cardiovascular side effects are mainly limited to the increased risk of hyperkalemia-induced arrhythmias in patients at risk for arrhythmias. Angina pectoris, arrhythmias, and orthostatic hypotension are reported in less than 1% of patients.[Ref]

Genitourinary

Genitourinary problems include rare complaints of impotence. Polyuria and urinary frequency are reported in less than 1% of patients.[Ref]

Share this Article
Latest News
Medical News

Obesity, unhealthy lifestyles may cause heart to age by 5–45 years

May 08, 2025
Aging: As little as 5 minutes of exercise may keep the brain healthy
Prostate cancer: Simple urine test may help with early detection
Cancer treatment side effects: Exercise may reduce pain, fatigue
Alzheimer's: Exercising in middle age may reduce beta-amyloid in brain...
Heart disease: Just 3 minutes of 'incidental activity' may lower...
Related Drugs
Fidanacogene Elaparvovec
Cerave Anti-Itch
Centrum Adult
Crovalimab
Cyltezo Prefilled Syringe
Zepbound Pen
Mylanta One
Uretron Ds
Medihoney Wound And Burn Dressing
Lidotrode

Other drugs

Name Drug Class Updated
Fidanacogene Elaparvovec Drugs 03-Oct-2024
Cerave Anti-Itch Drugs 02-Oct-2024
Centrum Adult Drugs 02-Oct-2024
Crovalimab Drugs 02-Oct-2024
Cyltezo Prefilled Syringe Drugs 01-Oct-2024
Zepbound Pen Drugs 30-Sep-2024
Mylanta One Drugs 27-Sep-2024
Uretron Ds Drugs 27-Sep-2024
Medihoney Wound And Burn Dressing Drugs 26-Sep-2024
Lidotrode Drugs 26-Sep-2024
Libervant Drugs 26-Sep-2024
Moderna Covid-19 Drugs 25-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024

Categories

  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health

About US

Welcome to TheMediTary.Com

Our website provides reliable and up-to-date information on various medical topics. We empower individuals to take charge of their health by simplifying complex medical jargon and providing practical tips and advice. We prioritize the privacy and confidentiality of our users and welcome feedback to improve our services.

Website use data of FDA and other sources

DMCA.com Protection Status Truste Protection Status Trust Mark Protection Status
HONcode logo We comply with the HONcode standard for trustworthy health information.
Quick Link
  • About Us
  • Contact Us
  • Editorial Policy
  • Privacy Policy
  • Accessibility Policy
  • Terms & Conditions
  • Disclaimer
  • DMCA
  • Do Not Sell My Personal Information
  • Sitemap
  • Care Notes
  • Health Guide
  • Professional
Drugs
  • New Drugs
  • Medical Answers
  • Drugs A-Z
  • Drug Classes
  • Drug Dosage
  • Pill Identifier
  • Consumer Infor
  • Side Effects
  • Inactive Ingredients
  • Pregnancy Warnings
  • Patient Tips
  • Treatments
News
  • Latest News
  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health
Find US
  • Medium
  • Google Site
  • Blogspot
  • API
  • Reddit
  • Tumblr
  • Scoop.it
  • Substack
  • Wordpress
  • Wix
  • Behance

© 2025 TheMediTary.Com All rights reserved. Operated by