Applies to colchicine / probenecid: oral tablet.

Get emergency medical help if you have any of these signs of an allergic reaction while taking colchicine/probenecid: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using colchicine and probenecid and call your doctor at once if you have:

• painful urination, severe pain in your side or lower back, blood in your urine, little or no urinating;

• fever, severe muscle weakness, mood changes, seizure (convulsions);

• easy bruising or bleeding, unusual weakness; or

• severe diarrhea, nausea, vomiting, or stomach pain.

Common side effects may include:

• mild nausea or stomach pain, loss of appetite;

• headache;

• dizziness;

• hair loss; or

• flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to colchicine / probenecid: oral tablet.

Nervous system

Probenecid:

Frequency not reported: Headache, dizziness

Colchicine:

Frequency not reported: Peripheral neuritis^[Ref]

Gastrointestinal

Probenecid:

Frequency not reported: Nausea, vomiting, abdominal pain, anorexia, sore gums

Colchicine:

Frequency not reported: Nausea, vomiting, abdominal pain, or diarrhea (may be particularly troublesome in the presence of peptic ulcer or spastic colon)^[Ref]

Renal

Probenecid:

Frequency not reported: Nephrotic syndrome, renal colic

Colchicine:

Frequency not reported: Renal damage with hematuria and oliguria have occurred with toxic doses

Hematologic

Probenecid:

Frequency not reported: Leukopenia, aplastic anemia, hemolytic anemia (may be due to genetic deficiency of glucose 6 phosphate dehydrogenase) and anemia

Colchicine:

Frequency not reported: Thrombocytopenia, pancytopenia, leukopenia, agranulocytosis, bone marrow failure, disseminated intravascular coagulation, aplastic anemia^[Ref]

Hepatic

Probenecid:

Frequency not reported: Hepatic necrosis.

Hypersensitivity

Probenecid:

Frequency not reported: Anaphylaxis, fever, urticaria, pruritus

Colchicine:

Frequency not reported: Urticaria^[Ref]

Dermatologic

Probenecid:

Frequency not reported: Dermatitis, alopecia, flushing

Colchicine:

Frequency not reported: Dermatitis, purpura, alopecia^[Ref]

Metabolic

Probenecid:

Frequency not reported: Precipitation of acute gouty arthritis^[Ref]

Musculoskeletal

Colchicine:

Frequency not reported: Muscular weakness^[Ref]

Genitourinary

Probenecid:

Frequency not reported: Urinary frequency, azoospermia, uric acid stones with or without hematuria, costovertebral pain^[Ref]

Other

At toxic doses, other side effects associated with colchicine have included severe diarrhea, generalized vascular damage, and renal damage with hematuria and oliguria.^[Ref]