Note: This document contains side effect information about carvedilol. Some dosage forms listed on this page may not apply to the brand name Coreg.

Summary

Common side effects of Coreg include: hyperglycemia. Other side effects include: angina pectoris, hypotension, nausea, orthostatic hypotension, rales, visual disturbance, and vomiting. Continue reading for a comprehensive list of adverse effects.

Applies to carvedilol: oral capsules, oral tablets.

Side effects include:

Patients with heart failure receiving immediate-release carvedilol (the active ingredient contained in Coreg) tablets: Dizziness, headache, fatigue, asthenia, arthralgia, hypotension, bradycardia, generalized edema, diarrhea, nausea, vomiting, hyperglycemia, weight gain, increased BUN, increased nonprotein nitrogen (NPN), increased cough, abnormal vision.

Patients with left ventricular dysfunction following MI receiving immediate-release carvedilol tablets: Similar to those in patients receiving the drug for the treatment of heart failure. Anemia, dyspnea, pulmonary edema also reported.

Patients with hypertension receiving immediate-release carvedilol tablets: Dizziness, bradycardia, diarrhea, insomnia, postural hypotension.

Patients with hypertension receiving extended-release carvedilol phosphate capsules: Nasopharyngitis, dizziness, nausea, peripheral edema.

For Healthcare Professionals

Applies to carvedilol: oral capsule extended release, oral tablet.

Metabolic

Common (1% to 10%): Weight increase, hypercholesterolemia, impaired blood glucose control (hyperglycemia, hypoglycemia) in patients with preexisting diabetes, gout, BUN increased, dehydration, hypervolemia^[Ref]

Cardiovascular

Very common (10% or more): Chest pain (15%), hypotension, cardiac failure

Common (1% to 10%): Bradycardia, edema, hypervolemia, orthostatic hypotension, hypertension, syncope, disturbances of peripheral circulation (e.g., cold extremities, peripheral vascular disease, exacerbation of intermittent claudication, Raynaud's phenomenon)

Uncommon (0.1% to 1%): Atrioventricular block, angina pectoris, tachycardia

Rare (less than 0.1%): Complete AV block, bundle branch block, myocardial ischemia, cerebrovascular disorder^[Ref]

Dermatologic

Uncommon (0.1% to 1%): Allergic exanthema, dermatitis, urticaria, pruritus, psoriatic and lichen planus like skin lesions, increased sweating, alopecia, erythematous rash, maculopapular rash, photosensitivity reaction

Rare (less than 0.1%): Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme^[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, diarrhea, vomiting, dyspepsia, abdominal pain, melena, periodontitis^[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection, micturition disorders, hematuria

Uncommon (0.1% to 1%): Erectile dysfunction

Postmarketing reports: Urinary incontinence in women^[Ref]

General

The frequency of adverse reactions is not dose-dependent, with the exception of dizziness, abnormal vision and bradycardia.^[Ref]

Hematologic

Common (1% to 10%): Anemia, purpura, prothrombin decrease

Rare (0.01% to 0.1%): Thrombocytopenia, aplastic anemia

Very rare (less than 0.01%): Leukopenia^[Ref]

Hepatic

Very rare (less than 0.01%): Alanine aminotransferase (ALT) increased, aspartate aminotransferase (AST) increased, gamma-glutamyltransferase (GGT) increased^[Ref]

Hypersensitivity

Rare (less than 0.1%): Hypersensitivity reactions (including anaphylactic reactions, angioedema, and urticaria)^[Ref]

Musculoskeletal

Common (1% to 10%): Pain in extremities, back pain, arthralgia, myalgia^[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, hyperesthesia, vertigo

Uncommon (0.1% to 1%): Presyncope, syncope, paresthesia,

Rare (0.01% to 0.1%): Convulsions, migraine, neuralgia, paresis, hypokinesia, neuralgia^[Ref]

Ocular

Common (1% to 10%): Visual impairment, abnormal vision, blurred vision, lacrimation decreased (dry eye), eye irritation^[Ref]

Other

Very common (10% or more): Fatigue (24%), asthenia

Common (1% to 10%): Pain, malaise, fever

Uncommon (0.1% to 1%): Tinnitus^[Ref]

Psychiatric

Common (1% to 10%): Depression, depressed mood, somnolence

Uncommon (0.1% to 1%): Sleep disorders, confusion, impaired concentration, abnormal thinking, paranoia, emotional lability, nervousness^[Ref]

Renal

Common (1% to 10%): Renal failure and renal function abnormalities (in patients with diffuse vascular disease and/or underlying renal insufficiency), albuminuria^[Ref]

Respiratory

Very common (10% or more): Upper respiratory tract infection (18%)

Common (1% to 10%): Bronchitis, pneumonia, dyspnea, pulmonary edema, asthma (in predisposed patients), sinusitis, pharyngitis, rhinitis, cough, rales^[Ref]