Applies to dimenhydrinate: oral solution, oral tablets, parenteral injection.

Side effects include:

Drowsiness, headache, blurred vision, tinnitus, dryness of the mouth and respiratory passages, incoordination, palpitation, dizziness, hypotension.

Paradoxical CNS stimulation in pediatric patients and occasionally in adults.

With IM injection: Pain at the injection site.

Because dimenhydrinate contains diphenhydramine, the possibility of other diphenhydramine-related adverse effects should also be considered.

For Healthcare Professionals

Applies to dimenhydrinate: compounding powder, injectable solution, oral liquid, oral tablet, oral tablet chewable.

General

The most frequently reported adverse reaction is drowsiness.^[Ref]

Cardiovascular

Frequency not reported: Tachycardia^[Ref]

Dermatologic

Frequency not reported: Skin rash^[Ref]

Gastrointestinal

Frequency not reported: Dry mouth, epigastric distress, nausea^[Ref]

Genitourinary

Frequency not reported: Difficult or painful urination^[Ref]

Metabolic

Frequency not reported: Anorexia^[Ref]

Nervous system

Frequency not reported: Drowsiness, dizziness, headache, excitation^[Ref]

Ocular

Frequency not reported: Blurred vision^[Ref]

Other

Frequency not reported: Lassitude^[Ref]

Psychiatric

Frequency not reported: Nervousness, restlessness, insomnia^[Ref]

Respiratory

Frequency not reported: Dry nose, dry throat, thickening of bronchial secretions^[Ref]