Usual Adult Dose for Abortion

Initial dose: 250 mcg (1 mL) once by deep IM injection, with a tuberculin syringe

Subsequent doses of 250 mcg (1 mL) may be administered at 1.5 to 3.5 hour intervals depending on uterine response.

An optional test dose of 100 mcg (0.4 mL) may be administered initially. The dose may be increased to 500 mcg (2 mL) if uterine contractility is judged to be inadequate after several doses of 250 mcg (1 mL).

Maximum total dose: 12 mg

Duration of therapy: No more than 2 continuous days

Uses:

• Aborting pregnancy between the 13 th and 20 th weeks of gestation (calculated from the first day of the last normal menstrual period)
• Failure of expulsion of the fetus during the course of treatment by another method
• Premature rupture of membranes in intrauterine methods with loss of drug and insufficient or absent uterine activity
• Requirement of a repeat intrauterine instillation of drug for expulsion of the fetus
• Inadvertent or spontaneous rupture of membranes in the presence of a previable fetus and absence of adequate activity for expulsion

Usual Adult Dose for Postpartum Bleeding

Initial dose: 250 mcg (1 mL) once by deep IM injection

Additional doses can be administered at intervals of 15 to 90 minutes, if necessary.

Maximum total dose: 2 mg (8 doses)

Comments: The need for additional injections and the administration interval should be determined by the attending physician as dictated by the course of clinical events.

Uses: Refractory postpartum hemorrhage due to uterine atony that has not responded to conventional methods of management.

Renal Dose Adjustments

Contraindicated

Liver Dose Adjustments

Contraindicated

Precautions

BOXED WARNINGS:

• Carboprost tromethamine, like other potent oxytocic agents, should be used only with strict adherence to recommended dosages.
• It should be used by medically trained personnel in a hospital which can provide immediate intensive care and acute surgical facilities.

Dialysis

Data not available

Other Comments

Administration advice:

• This drug should not be given intravenously.
• Consider pretreatment or coadministration of antiemetic and antidiarrheal drugs to decrease the incidence of gastrointestinal effects.