Drug Class: Upper respiratory combinations
Usual Adult Dose for Allergic Rhinitis
Chlorpheniramine-pseudoephedrine 2 mg-15 mg oral tablet, chewable:
2 tablets orally every 4 to 6 hours.
Chlorpheniramine-pseudoephedrine 2 mg-30 mg oral tablet, chewable:
2 tablets orally every 4 to 6 hours not to exceed 4 doses per day.
Chlorpheniramine-pseudoephedrine 4 mg-30 mg oral tablet, chewable, extended release:
1 to 2 tablets orally every 12 hours.
Chlorpheniramine-pseudoephedrine 5 mg-75 mg/5 mL oral suspension, extended release:
10 to 20 mL orally every 12 hours not to exceed 40 mL daily.
Chlorpheniramine-pseudoephedrine tannate 4 mg-30 mg oral tablet, chewable, extended release:
1 to 2 tablets orally every 12 hours.
Usual Adult Dose for Sinusitis
Chlorpheniramine-pseudoephedrine 2 mg-15 mg oral tablet, chewable:
2 tablets orally every 4 to 6 hours.
Chlorpheniramine-pseudoephedrine 2 mg-30 mg oral tablet, chewable:
2 tablets orally every 4 to 6 hours not to exceed 4 doses per day.
Chlorpheniramine-pseudoephedrine 4 mg-30 mg oral tablet, chewable, extended release:
1 to 2 tablets orally every 12 hours.
Chlorpheniramine-pseudoephedrine 5 mg-75 mg/5 mL oral suspension, extended release:
10 to 20 mL orally every 12 hours not to exceed 40 mL daily.
Chlorpheniramine-pseudoephedrine tannate 4 mg-30 mg oral tablet, chewable, extended release:
1 to 2 tablets orally every 12 hours.
Usual Pediatric Dose for Allergic Rhinitis
Chlorpheniramine-pseudoephedrine 0.8 mg-9 mg/mL oral liquid:
6 to 12 months: 0.5 mL orally four times daily not to exceed 4 doses per day.
1 to 2 years: 0.75 mL orally four times daily not to exceed 4 doses per day.
2 to 3 years: 1 mL orally four times daily not to exceed 4 doses per day.
Chlorpheniramine-pseudoephedrine 2 mg-15 mg oral tablet, chewable:
6 to 11 years: 1 tablet orally every 4 to 6 hours.
12 years or older: 2 tablets orally every 4 to 6 hours.
Chlorpheniramine-pseudoephedrine 2 mg-30 mg oral tablet, chewable
6 to 11 years: 1 tablet orally every 4 to 6 hours not to exceed 4 doses per day.
12 years or older: 2 tablets orally every 4 to 6 hours not to exceed 4 doses per day.
Chlorpheniramine-pseudoephedrine 4 mg-30 mg oral tablet, chewable, extended release:
2 to 5 years: 1/2 tablet orally every 12 hours.
6 to 11 years: 1/2 to 1 tablet orally every 12 hours.
12 years or older: 1 to 2 tablets orally every 12 hours.
Chlorpheniramine-pseudoephedrine 5 mg-75 mg/5 mL oral suspension, extended release:
2 to 5 years: 2.5 to 5 mL orally every 12 hours not to exceed 10 mL daily.
6 to 11 years: 5 to 10 mL orally every 12 hours not to exceed 20 mL daily.
12 years or older: 10 to 20 mL orally every 12 hours not to exceed 40 mL daily.
Chlorpheniramine-pseudoephedrine tannate 4 mg-30 mg oral tablet, chewable, extended release:
2 to 5 years: 1/2 tablet orally every 12 hours.
6 to 11 years: 1/2 to 1 tablet orally every 12 hours.
12 years or older: 1 to 2 tablets orally every 12 hours.
Usual Pediatric Dose for Sinusitis
Chlorpheniramine-pseudoephedrine 0.8 mg-9 mg/mL oral liquid:
6 to 12 months: 0.5 mL orally four times daily not to exceed 4 doses per day.
1 to 2 years: 0.75 mL orally four times daily not to exceed 4 doses per day.
2 to 3 years: 1 mL orally four times daily not to exceed 4 doses per day.
Chlorpheniramine-pseudoephedrine 2 mg-15 mg oral tablet, chewable:
6 to 11 years: 1 tablet orally every 4 to 6 hours.
12 years or older: 2 tablets orally every 4 to 6 hours.
Chlorpheniramine-pseudoephedrine 2 mg-30 mg oral tablet, chewable
6 to 11 years: 1 tablet orally every 4 to 6 hours not to exceed 4 doses per day.
12 years or older: 2 tablets orally every 4 to 6 hours not to exceed 4 doses per day.
Chlorpheniramine-pseudoephedrine 4 mg-30 mg oral tablet, chewable, extended release:
2 to 5 years: 1/2 tablet orally every 12 hours.
6 to 11 years: 1/2 to 1 tablet orally every 12 hours.
12 years or older: 1 to 2 tablets orally every 12 hours.
Chlorpheniramine-pseudoephedrine 5 mg-75 mg/5 mL oral suspension, extended release:
2 to 5 years: 2.5 to 5 mL orally every 12 hours not to exceed 10 mL daily.
6 to 11 years: 5 to 10 mL orally every 12 hours not to exceed 20 mL daily.
12 years or older: 10 to 20 mL orally every 12 hours not to exceed 40 mL daily.
Chlorpheniramine-pseudoephedrine tannate 4 mg-30 mg oral tablet, chewable, extended release:
2 to 5 years: 1/2 tablet orally every 12 hours.
6 to 11 years: 1/2 to 1 tablet orally every 12 hours.
12 years or older: 1 to 2 tablets orally every 12 hours.
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
The FDA has not approved use of over-the-counter cough and cold medications to children aged less than 2 years, and proper dosing for children in this age group has not been studied. Clinicians should be aware of the risk for serious illness or fatal overdose from administration of cough and cold medications to children aged less than 2 years. Clinicians should be certain that caregivers understand 1) the importance of administering cough and cold medications only as directed and 2) the risk for overdose if they administer additional medications that might contain the same ingredient.
Dialysis
Data not available
