Usual Adult Dose for Constipation

Oral: 50 to 400 mg (using any of the salt forms) orally administered in 1 to 4 equally divided doses each day.

Rectal: 200 to 283 mg rectally administered as an enema once or twice.
Alternative: 50 to 100 mg (docusate sodium liquid) added to a retention or flushing enema once a day.

Usual Pediatric Dose for Constipation

Oral:
less than 3 years: 10 to 40 mg (docusate sodium) orally divided in 1 to 4 doses.

3 to 6 years: 20 to 60 mg (docusate sodium) orally divided in 1 to 4 doses.

6 to 12 years: 40 to 150 mg (docusate sodium) orally divided in 1 to 4 doses.

greater than 12 years: 50 to 400 mg (using any of the salt forms) orally administered in 1 to 4 equally divided doses each day.

Rectal:
3 to 18 years: 50 to 100 mg (docusate sodium liquid) added to a retention or flushing enema once a day.
Alternative: 200 to 283 mg rectally administered as an enema once daily as needed for constipation.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Other Comments

Docusate should generally be used for a period of less than 1 week.

Frequently asked questions

• Which drugs cause opioid-induced constipation?