Usual Adult Dose for Rhinitis

Fluticasone furoate: 2 sprays (27.5 mcg/spray) in each nostril once a day
Fluticasone propionate: 1 or 2 sprays (50 mcg/spray) in each nostril once a day as needed

Comments:
Fluticasone furoate:

• When maximum benefit has been achieved and symptoms have been controlled, reducing the dosage to 55 mcg (1 spray in each nostril) once a day may be effective.

Usual Pediatric Dose for Rhinitis

2 to 11 years:
Fluticasone furoate: 1 spray (27.5 mcg/spray) in each nostril once a day

4 to 11 years:
Fluticasone propionate: 1 spray (50 mcg/spray) in each nostril once a day

12 years or older:
Fluticasone furoate: 2 sprays (27.5 mcg/spray) in each nostril once a day
Fluticasone propionate: 1 or 2 sprays (50 mcg/spray) in each nostril once a day as needed

Comments:
Fluticasone furoate:

• Children between 2 to 11 years not adequately responding to 55 mcg may use 110 mcg (2 sprays in each nostril) once a day.
• When maximum benefit has been achieved and symptoms have been controlled, reducing the dosage to 55 mcg (1 spray in each nostril) once a day may be effective.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Moderate or severe hepatic impairment: Use with caution

Precautions

Safety and efficacy have not been established in patients younger than 2 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• This drug should be administered by the intranasal route only.
• The nasal spray should be primed before using for the first time by shaking the contents well and releasing 6 sprays into the air away from the face.
• When the nasal spray has not been used for more than 30 days or if the cap has been left off the bottle for 5 days or longer, the pump should be primed again until a fine mist appears.
• The nasal spray should be shaken well before each use.

• The nasal device should be stored in the upright position with the cap in place between 15 and 30 C.
• Do not freeze or refrigerate.

• Endocrine: HPA-axis suppression (Urinary free-cortisol test, ACTH-stimulation test)