Usual Adult Dose for Dietary Supplement

500 to 1000 mg magnesium gluconate (27 to 54 mg elemental magnesium) orally once a day.

Usual Pediatric Dose for Dietary Supplement

Recommended dietary intake (RDA) for magnesium:
Birth to 6 months: 30 mg (adequate intake)
7 to 12 months: 75 mg (adequate intake)
1 to 3 years: 80 mg
4 to 8 years: 130 mg
9 to 13 years: 240 mg
14 to 18 years, male: 410 mg
14 to 18 years, female: 360 mg

Tolerable upper intake level (UL) for supplemental magnesium:
1 to 3 years: 65 mg
4 to 8 years: 110 mg
9 to 18 years: 350 mg

Comments:

• Magnesium gluconate contains 5% elemental magnesium

Renal Dose Adjustments

Use with caution.

• Magnesium elimination is decreased in renal impairment.
• Digestive magnesium absorption is normal or decreased in renal impairment.

Liver Dose Adjustments

Data not available

Dialysis

Dose adjustment(s) may be required; however, no specific guidelines have been suggested. Caution is recommended.

• Effects are similar in both hemodialysis and peritoneal dialysis.
• Hypermagnesemia is common with creatinine clearance under 10 mL/min.
• Mild hypermagnesemia is common with a dialysate magnesium of 0.75 mmol/L
• Serum magnesium was normal to low with a dialysate magnesium between 0.2 and 0.25 mmol/L.
• Ionized serum, ionized mononuclear and red blood cell measurements are not useful for hypermagnesemia detection.

Other Comments

Administration advice:

• Take with food to prevent side effects.
• Long acting formulations should not be crushed or chewed.
• If a dose is missed, take it as soon as remembered, unless it's almost time for the next dose, in which case it should be skipped. Do not double up doses.

• Notify your doctor if you experience side effects that are severe or don't go away, such as diarrhea and stomach upset.