Usual Adult Dose for Glaucoma

50 to 100 mg orally 2 or 3 times a day

Comments: May be used concomitantly with miotic and osmotic agents.

Use: Treatment of ocular conditions where lowering intraocular pressure is likely to be of therapeutic benefit, such as chronic open-angle glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma.

Renal Dose Adjustments

Contraindicated in marked renal dysfunction

Liver Dose Adjustments

Contraindicated in marked liver dysfunction

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Monitoring:

• Monitor for hematologic reactions common to all sulfonamides; perform a CBC and platelet count prior to initiating therapy and regularly thereafter.
• Monitor serum electrolytes periodically.

• Advise patients to seek immediate medical attention if any of the following sulfonamide reactions occur: anaphylaxis, fever, rash (including erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), crystalluria, renal calculus, bone marrow depression, thrombocytopenic purpura, hemolytic anemia, leukopenia, pancytopenia and agranulocytosis.
• Inform patients of the risk associated with coadministration of this drug and high-dose aspirin (anorexia, tachypnea, lethargy, coma, and death).