Vitamins
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Rayaldee Dosage

Drug Detail:Rayaldee (Calcifediol [ kal-sif-e-dye-ol ])

Generic Name: CALCIFEDIOL 30ug

Dosage Form: capsule, extended release

Drug Class: Vitamins

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

Important Dosage and Administration Information

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Ensure serum calcium is below 9.8 mg/dL before initiating treatment [see Warnings and Precautions (5.1)].
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Instruct patients to swallow RAYALDEE capsules whole.
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Instruct patients to skip a missed dose and to resume taking the medicine at the next regularly scheduled time. Do not administer an extra dose.

Starting Dose and Dose Titration

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The initial dose of RAYALDEE is 30 mcg administered orally once daily at bedtime.
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The maintenance dose of RAYALDEE should target serum total 25-hydroxyvitamin D levels between 30 and 100 ng/mL, intact parathyroid hormone (PTH) levels within the desired therapeutic range, serum calcium (corrected for low albumin) within the normal range and serum phosphorus below 5.5 mg/dL.
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Monitor serum calcium, serum phosphorus, serum total 25-hydroxyvitamin D and intact PTH levels at a minimum of 3 months after initiation of therapy or dose adjustment, and subsequently at least every 6 to 12 months.
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Increase the dose to 60 mcg orally once daily at bedtime after approximately 3 months, if intact PTH remains above the desired therapeutic range. Prior to raising the dose, ensure serum calcium is below 9.8 mg/dL, serum phosphorus is below 5.5 mg/dL and serum total 25-hydroxyvitamin D is below 100 ng/mL.
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Suspend dosing if intact PTH is persistently and abnormally low to reduce the risk of adynamic bone disease [see Warnings and Precautions (5.3)], if serum calcium is consistently above the normal range to reduce the risk of hypercalcemia [see Warnings and Precautions (5.1)], or if serum total 25-hydroxyvitamin D is consistently above 100 ng/mL. Restart at a reduced dose after these laboratory values have normalized.
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