Colony stimulating factors
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Stimufend Dosage

Drug Detail:Stimufend (Pegfilgrastim [ peg-fil-gras-tim ])

Generic Name: PEGFILGRASTIM 6mg in 0.6mL

Dosage Form: injection, solution

Drug Class: Colony stimulating factors

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

Patients with Cancer Receiving Myelosuppressive Chemotherapy

The recommended dosage of Stimufend is a single subcutaneous injection of 6 mg administered once per chemotherapy cycle. For dosing in pediatric patients weighing less than 45 kg, refer to Table 1. Do not administer Stimufend between 14 days before and 24 hours after administration of cytotoxic chemotherapy.

Administration

Stimufend is administered subcutaneously via a single-dose prefilled syringe for manual use.

Prior to use, remove the carton from the refrigerator and allow the Stimufend prefilled syringe to reach room temperature for a minimum of 30 minutes. Discard any prefilled syringe left at room temperature for greater than 72 hours.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not administer Stimufend if discoloration or particulates are observed.

The needle cap on the pre-filled syringes contains dry natural rubber (derived from latex); persons with latex allergies should not administer these products.

Pediatric Patients weighing less than 45 kg

The Stimufend pre-filled syringe is not designed to allow for direct administration of doses less than 0.6 mL (6 mg). The syringe does not bear graduation marks, which are necessary to accurately measure doses of Stimufend less than 0.6 mL (6 mg) for direct administration to patients. Thus, the direct administration to patients requiring dosing of less than 0.6 mL (6 mg) is not recommended due to the potential for dosing errors. Refer to Table 1.

Table 1. Dosing of Stimufend for Pediatric Patients Weighing Less Than 45 kg

*For pediatric patients weighing less than 10 kg, administer 0.1 mg/kg (0.01 mL/kg) of Stimufend.

Body Weight
Stimufend Dose
Volume to Administer
Less than 10 kg* See below* See below*
10 - 20 kg 1.5 mg 0.15 mL
21 - 30 kg 2.5 mg 0.25 mL
31 - 44 kg 4 mg 0.4 mL
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