By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo

TheMediTary.Com

Medical Information, Documents, News - TheMediTary.Com

  • Home
  • News
  • Drugs
  • Drugs A-Z
  • Medical Answers
  • About Us
  • Contact
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo
Search Drugs
  • Drugs
    • Latest Drugs
    • Drugs A-Z
    • Medical Answers
  • News
    • FDA Alerts
    • Medical News
    • Health
    • Consumer Updates
    • Children's Health
  • More TheMediTary.Com
    • About Us
    • Contact
Follow US
Home > Drugs > Miscellaneous antineoplastics > Erwinaze > Erwinaze Side Effects
Miscellaneous antineoplastics

Erwinaze Side Effects

Note: This document contains side effect information about asparaginase erwinia chrysanthemi. Some dosage forms listed on this page may not apply to the brand name Erwinaze.

Summary

Common side effects of Erwinaze include: anaphylaxis. Other side effects include: pancreatitis and severe hypersensitivity reaction. Continue reading for a comprehensive list of adverse effects.

Applies to asparaginase erwinia chrysanthemi: injection powder for solution. Other dosage forms:

  • intramuscular solution

Serious side effects of Erwinaze

Along with its needed effects, asparaginase erwinia chrysanthemi (the active ingredient contained in Erwinaze) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking asparaginase erwinia chrysanthemi:

More common

  • Agitation
  • back pain
  • black, tarry stools
  • bleeding gums
  • bloating
  • blood in the urine or stools
  • blurred vision
  • chest pain
  • chills
  • coma
  • confusion
  • constipation
  • cough or hoarseness
  • difficulty in walking
  • dizziness
  • drooping eyelids
  • drowsiness
  • dry mouth
  • lightheadedness
  • fainting
  • fast heartbeat
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • hallucinations
  • headache
  • increased hunger
  • increased menstrual flow or vaginal bleeding
  • increased thirst
  • increased urination
  • indigestion
  • irritability
  • jaw pain
  • lower back or side pain
  • mood or mental changes
  • nosebleeds
  • numbness or tingling in the fingers and toes
  • pain in the fingers and toes
  • pain in the testicles
  • pains in the chest, groin, or legs, especially calves of the legs
  • pains in stomach, side, or abdomen, possibly radiating to the back
  • painful or difficult urination
  • pale skin
  • paralysis
  • pinpoint red spots on the skin
  • prolonged bleeding from cuts
  • rapid, shallow breathing
  • seizures
  • severe headaches of sudden onset
  • sleepiness or unusual drowsiness
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stiff neck
  • stomach pain
  • sudden loss of coordination
  • sudden onset of slurred speech
  • sudden vision changes
  • sweating
  • swollen glands
  • trouble breathing
  • unexplained weight loss
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • yellow eyes or skin

Less common

  • Chest tightness
  • difficulty swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • hives, itching, skin rash
  • increase in frequency of seizures
  • loss of appetite
  • loss of consciousness
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

Incidence not known

  • Diarrhea
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
  • unpleasant breath odor
  • vomiting of blood

Other side effects of Erwinaze

Some side effects of asparaginase erwinia chrysanthemi may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For Healthcare Professionals

Applies to asparaginase erwinia chrysanthemi: injectable powder for injection, intramuscular solution.

General

The most frequent nonhematological serious adverse reactions (in greater than 5% of patients) were febrile neutropenia, infection, drug hypersensitivity, pyrexia, nausea, dehydration, stomatitis, acute kidney injury, pancreatitis, diarrhea, and viral infection.[Ref]

Hypersensitivity

Very common (15% or more): Hypersensitivity reactions including rash, infusion related reaction, lip swelling, periorbital edema, throat irritation, urticaria, dry skin, eczema, erythema, hand dermatitis, rash maculo-papular, rash papular (21% to 24%)

Very rare (less than 0.01%): Anaphylaxis[Ref]

Gastrointestinal

Very common (15% or more): Stomatitis (24% to 27%), nausea (45% to 47%), abdominal pain (21% to 25%), diarrhea (18% to 25%), pancreatitis (12% to 22%)[Ref]

Nervous system

Very common (15% or more): Headache (22% to 36%), peripheral neuropathy including peripheral motor neuropathy, neuropathy peripheral, peripheral sensory neuropathy (6% to 15%)[Ref]

Dermatologic

Common (1% to 10%): Rash (19%)

Frequency not reported: Toxic epidermal necrosis[Ref]

Hepatic

Very common (15% or more): Abnormal liver tests (70% to 75%)

Frequency not reported: Hepatomegaly, cholestatic jaundice[Ref]

Hematologic

Very common (15% or more): Febrile neutropenia (27% to 30%), hemorrhage including contusion, epistaxis, catheter site hemorrhage, petechiae, hematochezia, menorrhagia, mouth hemorrhage, increased tendency to bruise, rectal hemorrhage (24 to 27%)

Frequency not reported: clotting factor decreased, antithrombin III decreased, protein C decreased, protein S decreased, fibrinogen decreased[Ref]

Cardiovascular

Very common (reported as 15% or more): Tachycardia (16 to 18%)[Ref]

Metabolic

Very common (15% or more): Hyperglycemia (12% to 21%), hypokalemia (9% to 22%, dehydration (12% to 15%), decreased appetite (21% to 27%)

Rare (0.01% to 0.1%): Diabetic ketoacidosis

Very rare (less than 0.01%): Hyperammonemia[Ref]

Other

Infections:

Very common (15% or more): Including sepsis, upper respiratory tract infection, enterocolitis infectious, skin infection, bacteremia, paronychia, pneumonia, otitis externa, soft tissue infection, abdominal infection, conjunctivitis, device related infection, folliculitis, lymph gland infection, necrotizing fasciitis, perirectal abscess, peritonsillar abscess, sinusitis, subcutaneous abscess, wound infection (27% to 36%)[Ref]

Musculoskeletal

Very common (15% or more): Musculoskeletal pain, including arthralgia, back pain, musculoskeletal chest pain, musculoskeletal pain, myalgia, pain in extremity (35% to 45%)[Ref]

Psychiatric

Very common (15% or more): Insomnia (4% to 15%)[Ref]

Respiratory

Very common (15% or more): Cough (15%)[Ref]

Share this Article
Latest News
Medical News

Obesity, unhealthy lifestyles may cause heart to age by 5–45 years

May 08, 2025
Aging: As little as 5 minutes of exercise may keep the brain healthy
Prostate cancer: Simple urine test may help with early detection
Cancer treatment side effects: Exercise may reduce pain, fatigue
Alzheimer's: Exercising in middle age may reduce beta-amyloid in brain...
Heart disease: Just 3 minutes of 'incidental activity' may lower...
Related Drugs
Fidanacogene Elaparvovec
Cerave Anti-Itch
Centrum Adult
Crovalimab
Cyltezo Prefilled Syringe
Zepbound Pen
Mylanta One
Uretron Ds
Medihoney Wound And Burn Dressing
Lidotrode

Other drugs

Name Drug Class Updated
Fidanacogene Elaparvovec Drugs 03-Oct-2024
Cerave Anti-Itch Drugs 02-Oct-2024
Centrum Adult Drugs 02-Oct-2024
Crovalimab Drugs 02-Oct-2024
Cyltezo Prefilled Syringe Drugs 01-Oct-2024
Zepbound Pen Drugs 30-Sep-2024
Mylanta One Drugs 27-Sep-2024
Uretron Ds Drugs 27-Sep-2024
Medihoney Wound And Burn Dressing Drugs 26-Sep-2024
Lidotrode Drugs 26-Sep-2024
Libervant Drugs 26-Sep-2024
Moderna Covid-19 Drugs 25-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024

Categories

  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health

About US

Welcome to TheMediTary.Com

Our website provides reliable and up-to-date information on various medical topics. We empower individuals to take charge of their health by simplifying complex medical jargon and providing practical tips and advice. We prioritize the privacy and confidentiality of our users and welcome feedback to improve our services.

Website use data of FDA and other sources

DMCA.com Protection Status Truste Protection Status Trust Mark Protection Status
HONcode logo We comply with the HONcode standard for trustworthy health information.
Quick Link
  • About Us
  • Contact Us
  • Editorial Policy
  • Privacy Policy
  • Accessibility Policy
  • Terms & Conditions
  • Disclaimer
  • DMCA
  • Do Not Sell My Personal Information
  • Sitemap
  • Care Notes
  • Health Guide
  • Professional
Drugs
  • New Drugs
  • Medical Answers
  • Drugs A-Z
  • Drug Classes
  • Drug Dosage
  • Pill Identifier
  • Consumer Infor
  • Side Effects
  • Inactive Ingredients
  • Pregnancy Warnings
  • Patient Tips
  • Treatments
News
  • Latest News
  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health
Find US
  • Medium
  • Google Site
  • Blogspot
  • API
  • Reddit
  • Tumblr
  • Scoop.it
  • Substack
  • Wordpress
  • Wix
  • Behance

© 2025 TheMediTary.Com All rights reserved. Operated by