Applies to fostamatinib: oral tablet.
Warning
Fostamatinib can raise your blood pressure, sometimes to dangerous levels. Fostamatinib may also cause liver problems, severe diarrhea, and infections.
Call your doctor if you have: headaches, chest pain, shortness of breath, severe diarrhea, stomach pain, fever, or sore throat.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
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severe diarrhea;
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stomach pain (upper right side);
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dark urine, jaundice (yellowing of the skin or eyes);
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headaches, chest pain, shortness of breath; or
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fever, sore throat, or other signs of infection.
Your fostamatinib doses may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
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increased blood pressure;
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diarrhea, nausea, stomach pain;
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abnormal liver function tests;
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chest pain;
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dizziness, tiredness;
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rash; or
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cold symptoms such as stuffy nose, sneezing, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to fostamatinib: oral tablet.
Hematologic
Common (1% to 10%): Neutropenia[Ref]
Hepatic
Very common (10% or more): ALT increased (11%)
Common (1% to 10%): AST increased[Ref]
Respiratory
Very common (10% or more): Respiratory infection (11%)[Ref]
Other
Common (1% to 10%): Fatigue[Ref]
Nervous system
Very common (10% or more): Dizziness (11%)[Ref]
Cardiovascular
Very common (10% or more): Hypertension (28%)[Ref]
Dermatologic
Common (1% to 10%): Rash (e.g., rash erythematous, rash macular)[Ref]
Gastrointestinal
Very common (10% or more): Diarrhea (31%), nausea (19%)
Common (1% to 10%): Abdominal pain[Ref]
