Applies to guselkumab: parenteral injection.

Side effects include:

Most common adverse effects (≥1%) include upper respiratory tract infection, headache, injection site reactions, arthralgia, bronchitis, diarrhea, gastroenteritis, tinea infections, herpes simplex infections.

For Healthcare Professionals

Applies to guselkumab: subcutaneous solution.

Immunologic

Very common (10% or more): Infections (23%)

Common (1% to 10%): Tinea infections, herpes simplex infections, immunogenicity^[Ref]

Local

Common (1% to 10%): Injection site reactions (e.g., injection site erythema, bruising, hematoma, hemorrhage, swelling, edema, pruritus, pain, discoloration, induration, inflammation, urticaria)^[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia^[Ref]

Hepatic

Common (1% to 10%): Elevated liver enzymes^[Ref]

Respiratory

Very common (10% or more): Respiratory tract infection (e.g., nasopharyngitis, upper respiratory tract infection, pharyngitis, viral upper respiratory tract infection) (14%)^[Ref]

Nervous system

Common (1% to 10%): Headache^[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, gastroenteritis (including viral gastroenteritis)^[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity

Frequency not reported: Anaphylaxis^[Ref]

Dermatologic

Common (1% to 10%): Urticaria, rash^[Ref]