Applies to ixekizumab: parenteral injection.

Side effects include:

Injection site reactions, upper respiratory tract infections (e.g., nasopharyngitis, rhinovirus infection), nausea, tinea infections.

For Healthcare Professionals

Applies to ixekizumab: subcutaneous solution.

General

Most commonly reported adverse reactions with a frequency of 1% or greater were injection site reactions, upper respiratory tract infections, nausea, and tinea infections.

Cardiovascular

Common (1% to 10%): Hypertension

Dermatologic

Common (1% to 10%): Urticaria, herpes simplex (mucocutaneous)

Uncommon (0.1% to 1%): Angioedema, cellulitis, rash, eczema, pruritus, alopecia^[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, diarrhea, oral herpes, pharyngitis, oropharyngeal pain

Uncommon (0.1% to 1%): Oral candidiasis, inflammatory bowel disease, abdominal pain

Rare (0.01% to 0.1%): Oesophageal candidiasis

Frequency not reported: Crohn's disease, ulcerative colitis, gastroenteritis^[Ref]

Genitourinary

Common (1% to 10%): Vulvovaginal candidiasis, menstrual disorder, irregular menstruation, uterine dilation, curettage

Uncommon (0.1% to 1%): Ovarian cyst

Frequency not reported: Bacterial vaginosis, bartholinitis

Hematologic

Very common (10% or more): Neutropenia (Up to 11%)

Common (1% to 10%): Thrombocytopenia, anemia^[Ref]

Hypersensitivity

Frequency not reported: Serious hypersensitivity reactions (e.g., anaphylaxis, angioedema, urticaria)^[Ref]

Immunologic

Very common (10% or more): Infections ( Up to 27%), immunogenicity (Up to 22%)

Common (1% to 10%): Tinea infections, influenza

Uncommon (0.1% to 1%): Serious infections^[Ref]

Local

Very common (10% or more): Injection site reactions (Up to 17%)

Frequency not reported: Erythema, pain

Postmarketing reports: Esophageal candidiasis^[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia, back pain, myalgia

Uncommon (0.1% to 1%): Musculoskeletal pain, neck pain, non-cardiac chest pain

Nervous system

Uncommon (0.1% to 1%): Headache, dizziness

Ocular

Common (1% to 10%): Conjunctivitis

Uncommon (0.1% to 1%): Iridocyclitis, eye pain^[Ref]

Other

Common (1% to 10%): Anti-drug antibodies development

Uncommon (0.1% to 1%): Fatigue, pyrexia

Psychiatric

Common (1% to 10%): Depression

Respiratory

Very common (10% or more): Upper respiratory tract infections (including nasopharyngitis and rhinovirus infection) (Up to 16%)

Uncommon (0.1% to 1%): Rhinitis, bronchitis, sinusitis^[Ref]

Metabolic

Uncommon (0.1% to 1%): Increased blood creatine phosphokinase, increased aspartate aminotransferase

Renal

Common (1% to 10%): Dysuria