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Home > Drugs > Proteasome inhibitors > Kyprolis > Kyprolis Side Effects
Proteasome inhibitors

Kyprolis Side Effects

Note: This document contains side effect information about carfilzomib. Some dosage forms listed on this page may not apply to the brand name Kyprolis.

Summary

Common side effects of Kyprolis include: asthenia, arthralgia, dyspnea, fever, thrombocytopenia, vomiting, and chills. Other side effects include: congestive heart failure, pulmonary edema, and reduced ejection fraction. Continue reading for a comprehensive list of adverse effects.

Applies to carfilzomib: parenteral powder for injection.

Side effects include:

Fatigue, anemia, nausea, dyspnea, diarrhea, pyrexia.

Laboratory abnormalities: Anemia, thrombocytopenia, increased Scr, lymphopenia, neutropenia, hypokalemia, hypomagnesemia, leukopenia, increased AST concentrations, hyperglycemia, hypercalcemia, hypophosphatemia, hyponatremia.

For Healthcare Professionals

Applies to carfilzomib: intravenous powder for injection.

Hematologic

Very common (10% or more): Anemia (47%), thrombocytopenia (36%), lymphopenia (24%), neutropenia (21%), leukopenia (14%)

Common (1% to 10%): Deep vein thrombosis

Uncommon (0.1% to 1%): Hemolytic uremic syndrome (HUS)

Rare (less than 0.1%): Thrombotic thrombocytopenic purpura (TTP), thrombotic microangiopathy, hemorrhage[Ref]

Cardiovascular

Very common (10% or more): Hypertension (14%)

Common (1% to 10%): Cardiac failure (i.e., pulmonary edema, decreased ejection fraction), atrial fibrillation, tachycardia, palpitations, flushing

Uncommon (0.1% to 1%): Cardiac arrest, myocardial infarction, myocardial ischemia, pericarditis, pericardial effusion

Rare (less than 0.1%): Hypertensive crisis[Ref]

Hepatic

Very common (10% or more): Increased aspartate aminotransferase (13%)

Common (1% to 10%): Increased alanine aminotransferase, increased gamma-glutamyltransferase, hyperbilirubinemia

Uncommon (0.1% to 1%): Hepatic failure, cholestasis[Ref]

Nervous system

Very common (10% or more): Headache (28%), peripheral neuropathy (14%), dizziness (13%), hypoesthesia (12%), dizziness

Postmarketing reports: Posterior reversible encephalopathy syndrome, paresthesia, hypoesthesia

Uncommon (0.1% to 1%): Intracranial hemorrhage, cerebrovascular accident

Rare (less than 0.1%): Posterior reversible encephalopathy syndrome (PRES)[Ref]

Other

Very common (10% or more): Fatigue (56%), pyrexia (30%), peripheral edema (24%), chills (16%), arthralgia (16%), asthenia (14%), pain (12%), infusion reaction

Common (1% to 10%): Dysphonia

Uncommon (0.1% to 1%): Multi-organ failure[Ref]

Respiratory

Very common (10% or more): Dyspnea (35%), upper respiratory tract infection (28%), cough (26%), pneumonia (13%), nasopharyngitis

Common (1% to 10%): Pulmonary hypertension, bronchitis, pulmonary embolism, pulmonary edema, epistaxis, rhinitis, wheezing

Uncommon (0.1% to 1%): Lung infection

Rare (less than 0.1%): Acute respiratory distress syndrome (ARDS), acute respiratory failure, pulmonary hemorrhage, interstitial lung disease, pneumonitis[Ref]

Gastrointestinal

Very common (10% or more): Nausea (45%), diarrhea (33%), vomiting (22%), constipation (21%), abdominal pain

Common (1% to 10%): Oropharyngeal pain, dyspepsia, toothache

Rare (less than 0.1%): GI hemorrhage, GI perforation[Ref]

Renal

Very common (10% or more): Increased blood creatinine (24%)

Common (1% to 10%): Acute renal failure, renal failure, renal impairment, decreased creatinine renal clearance[Ref]

Metabolic

Very common (10% or more): Hypokalemia (14%), hypomagnesemia (14%), anorexia (12%), hyperglycemia (12%), hypercalcemia (11%), hypophosphatemia (11%), hyponatremia (10%)

Common (1% to 10%): Dehydration, hyperkalemia, hypocalcemia, hyperuricemia, hypoalbuminemia

Uncommon (0.1% to 1%): Tumor lysis syndrome[Ref]

Musculoskeletal

Very common (10% or more): Back pain (20%), extremity pain (13%), chest wall pain (11%), arthralgia, muscle spasms

Common (1% to 10%): Musculoskeletal pain, musculoskeletal chest pain, bone pain, myalgia, muscular weakness[Ref]

Psychiatric

Very common (10% or more): Insomnia (17.9%)

Common (1% to 10%): Anxiety[Ref]

Immunologic

Common (1% to 10%): Herpes zoster reactivation, sepsis, influenza, viral infection[Ref]

Dermatologic

Common (1% to 10%): Rash, pruritus, erythema, hyperhidrosis[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Drug hypersensitivity[Ref]

Ocular

Common (1% to 10%): Cataract, blurred vision

Frequency not reported: Blindness and other adverse visual disturbances (due to PRES)[Ref]

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