Applies to lanadelumab: subcutaneous solution.
Serious side effects of Lanadelumab
Along with its needed effects, lanadelumab may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking lanadelumab:
More common
- Rash
Less common
- Chest tightness
- fast heartbeat
- fever
- hives, itching
- hoarseness
- irritation
- joint pain, stiffness, or swelling
- redness of the skin
- swelling of the eyelids, face, lips, hands, or feet
- trouble breathing or swallowing
Other side effects of Lanadelumab
Some side effects of lanadelumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- body aches or pain
- chills
- cough
- difficulty in moving
- dizziness
- ear congestion
- headache
- loss of voice
- muscle ache, cramps, pain, or stiffness
- sneezing
- stuff or runny nose
- sore throat
- unusual tiredness or weakness
Less common
- Diarrhea
For Healthcare Professionals
Applies to lanadelumab: subcutaneous solution.
General
The most common adverse reactions were injection site reactions, upper respiratory infection, headache, rash, myalgia, dizziness, and diarrhea.[Ref]
Respiratory
Very common (10% or more): Upper respiratory infection (up to 44%)
Frequency not reported: Viral upper respiratory infection[Ref]
Nervous system
Very common (10% or more): Headache (up to 33%), dizziness (up to 10%)
Frequency not reported: Tension headache, sinus headache[Ref]
Immunologic
Very common (10% or more): Anti-drug antibody (ADA)-positive sample during treatment with this drug (12%)
Common (1% to 10%): Hypersensitivity[Ref]
Musculoskeletal
Very common (10% or more): Myalgia (up to 11%)[Ref]
Gastrointestinal
Very common (10% or more): Diarrhea (up to 11%)[Ref]
Hepatic
Common (1% to 10%): ALT increased, AST increased, ALT or AST greater than 8 times the upper limit of normal[Ref]
Local
Very common (10% or more): Injection site reactions (up to 56%)
Frequency not reported: Pain, erythema, bruising, hematoma, hemorrhage, pruritus, swelling, induration, paresthesia, warmth, edema, rash[Ref]
Dermatologic
Very common (10% or more): Rash (up to 10%)
Frequency not reported: Maculopapular rash, erythematous rash[Ref]
