Note: This document contains side effect information about benzoyl peroxide / clindamycin topical. Some dosage forms listed on this page may not apply to the brand name Onexton.
Applies to benzoyl peroxide/clindamycin topical: external gel, external kit.
Serious side effects of Onexton
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Very bad irritation where this drug is used.
Other side effects of Onexton
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Irritation where this drug is used.
- Dry skin.
- Itching.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
For Healthcare Professionals
Applies to benzoyl peroxide/clindamycin topical: topical gel, topical kit.
General
The most frequently reported side effects were erythema, scaling, peeling, dry skin, and itching.[Ref]
Dermatologic
Very common (10% or more): Erythema (up to 28%), scaling (up to 19%), peeling (up to 17%), dry skin (up to 15%), itching (up to 15%)
Common (1% to 10%): Pruritus, sunburn, burning, stinging
Uncommon (0.1% to 1%): Contact dermatitis, rash, acne worsened
Postmarketing reports: Urticaria[Ref]
Gastrointestinal
Frequency not reported: Colitis
Postmarketing reports: Pseudomembranous colitis, hemorrhagic diarrhea, diarrhea, abdominal pain[Ref]
Immunologic
Postmarketing reports: Anaphylaxis, allergic reaction[Ref]
Local
Common (1% to 10%): Application site reaction
Uncommon (0.1% to 1%): Application site pain, application site exfoliation, application site irritation
Postmarketing reports: Discoloration[Ref]
Nervous system
Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Paresthesia[Ref]
