Note: This document contains side effect information about carboplatin. Some dosage forms listed on this page may not apply to the brand name Paraplatin.
Summary
Common side effects of Paraplatin include: hypersensitivity reaction, nausea and vomiting, anemia, vomiting, and genitourinary signs and symptoms. Continue reading for a comprehensive list of adverse effects.
Applies to carboplatin: parenteral injection concentrate, parenteral powder for injection.
Warning
- Use only under the supervision of a qualified clinician experienced in the use of cytotoxic therapy.1 Use only when adequate treatment facilities for appropriate management of therapy and complications are available.1
- Dose-related bone marrow suppression may result in infection and/or bleeding.1 Anemia may be cumulative and may require transfusion support.1
- Vomiting is a common adverse effect.1 201
- Anaphylactic-like reactions may occur within minutes of administration.1 Administer epinephrine, corticosteroids, and/or antihistamines to relieve symptoms.1
Side effects include:
Thrombocytopenia, neutropenia, leukopenia, anemia, nausea, vomiting, electrolyte abnormalities (hypocalcemia, hypokalemia, hypomagnesemia, hyponatremia), alkaline phosphatase elevations.
For Healthcare Professionals
Applies to carboplatin: intravenous powder for injection, intravenous solution.
Hematologic
Very common (10% or more): Leukopenia (98%), neutropenia (97%), anemia (91%), thrombocytopenia (70%), bleeding (10%)
Rare (less than 0.1%): Febrile neutropenia
Frequency not reported: Bone marrow failure, hemolytic-uremic syndrome[Ref]
Gastrointestinal
Very common (10% or more): Nausea (93%), vomiting (84%), adverse GI effects (50%), abdominal pain
Common (1% to 10%): Mucositis, diarrhea, constipation
Frequency not reported: Stomatitis, pancreatitis[Ref]
Nervous system
Very common (10% or more): Central neurotoxicity (26%), peripheral neuropathy (15%)
Common (1% to 10%): Other sensory side effects, paresthesia, decrease of osteotendinous reflexes, sensory disturbance, dysgeusia
Frequency not reported: Cerebrovascular accident, reversible posterior leukoencephalopathy syndrome (RPLS)[Ref]
Hepatic
Very common (10% or more): Alkaline phosphatase elevations (29%), SGOT elevations (20%), aspartate aminotransferase increased, liver function test abnormal
Common (1% to 10%): Bilirubin elevations[Ref]
Renal
Very common (10% or more): Blood urea elevations (17%), creatinine renal clearance decreased[Ref]
Other
Very common (10% or more): Pain (44%), asthenia (41%), ototoxicity (12%)
Common (1% to 10%): Asthenia
Frequency not reported: Malaise[Ref]
Hypersensitivity
Common (1% to 10%): Hypersensitivity, anaphylactoid type reaction[Ref]
Metabolic
Very common (10% or more): Magnesium loss (61%), potassium loss (16%), calcium loss (16%), sodium loss (10%)
Rare (less than 0.1%): Hyponatremia
Frequency not reported: Dehydration, anorexia, tumor lysis syndrome[Ref]
Ocular
Rare (less than 0.1%): Visual disturbance (including rare cases of loss of vision)[Ref]
Immunologic
Very common (10% or more): Infection (14%)
Local
Frequency not reported: Injection site necrosis, injection site reaction, injection site extravasation, injection site erythema
Musculoskeletal
Common (1% to 10%): Musculoskeletal disorder[Ref]
Genitourinary
Common (1% to 10%): Urogenital disorder[Ref]
Oncologic
Frequency not reported: Neoplasms (e.g., benign, malignant, unspecified) including cysts and polyps[Ref]
Respiratory
Common (1% to 10%): Respiratory disorder, interstitial lung disease, bronchospasm
Frequency not reported: Pneumonia[Ref]
Cardiovascular
Common (1% to 10%): Cardiovascular disorder
Frequency not reported: Cardiac failure, embolism, hypertension, hypotension[Ref]
Dermatologic
Very common (10% or more): Alopecia (49%), skin disorder
Frequency not reported: Urticaria, rash, erythema, pruritus[Ref]
