Uses of Skyrizi:

• It is used to treat plaque psoriasis.

What do I need to tell my doctor BEFORE I take Skyrizi?

• If you are allergic to Skyrizi (150 MG Dose) (risankizumab); any part of Skyrizi (150 MG Dose) (risankizumab); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
• If you have an infection.
• If you have active TB (tuberculosis).
• If you have recently had a live vaccine

This is not a list of all drugs or health problems that interact with Skyrizi (150 MG Dose) (risankizumab).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Skyrizi (150 MG Dose) (risankizumab) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Skyrizi?

• Tell all of your health care providers that you take Skyrizi (150 MG Dose) (risankizumab). This includes your doctors, nurses, pharmacists, and dentists.
• Make sure you are up to date with all your vaccines before treatment with Skyrizi (150 MG Dose) (risankizumab).
• You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
• You will need a TB (tuberculosis) test before starting Skyrizi (150 MG Dose) (risankizumab).
• Talk with your doctor before getting any vaccines. Use of some vaccines with Skyrizi (150 MG Dose) (risankizumab) may either raise the chance of an infection or make the vaccine not work as well.
• Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

How is this medicine (Skyrizi) best taken?

Use Skyrizi (150 MG Dose) (risankizumab) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• It is given as a shot into the fatty part of the skin on the top of the thigh, belly area, or upper arm.
• If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot.
• Do not shake.
• If the dose is more than 1 injection, give the injections into 2 different places.
• Do not give into tender, bruised, red, or hard skin.
• Do not give into skin that is affected by psoriasis.
• To make the injection feel better, take Skyrizi (150 MG Dose) (risankizumab) out of the refrigerator and allow it to sit at room temperature for up to 30 minutes before use. Do not remove the cap or cover. Do not heat Skyrizi (150 MG Dose) (risankizumab).
• This product is clear but may contain small white or clear particles. You may also see one or more air bubbles. Do not use if the solution is cloudy, leaking, or has large particles.
• This medicine is colorless to a faint yellow. Do not use if the solution changes color.
• Each prefilled syringe is for one use only.
• Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.

What do I do if I miss a dose?

• Take a missed dose as soon as you think about it and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.
• If you are not sure what to do if you miss a dose, call your doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
• Flu-like signs.
• Shortness of breath.
• Weight loss.
• Warm, red, or painful skin or sores on the body.

What are some other side effects of Skyrizi?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Signs of a common cold.
• Feeling tired or weak.
• Irritation where the shot is given.
• Headache.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Skyrizi?

• Store in a refrigerator. Do not freeze.
• Do not use if it has been frozen.
• Store in the original container to protect from light.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer Information Use and Disclaimer

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Skyrizi (150 MG Dose) (risankizumab) is refilled. If you have any questions about Skyrizi (150 MG Dose) (risankizumab), please talk with the doctor, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Frequently asked questions

• What are monoclonal antibodies?
• What causes Plaque Psoriasis?
• How long does it take for Skyrizi to work?
• What's the dosing schedule for Skyrizi?
• Can you drink alcohol while taking Skyrizi?
• What is Skyrizi used for and how does it work?
• How is Skyrizi injection administered?

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