Uses of Hyaluronate and Derivatives Injection:

• It is used to treat arthritis of the knee.
• It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Hyaluronate and Derivatives Injection?

• If you have an allergy to hyaluronic acid or any other part of hyaluronate and derivatives injection (knee).
• If you are allergic to hyaluronate and derivatives injection (knee); any part of hyaluronate and derivatives injection (knee); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
• If you are using a product that contains ammonium salts or chlorhexidine to clean the area.
• If you have bleeding problems.
• If you have an infection or skin problem where the shot will be given.

This is not a list of all drugs or health problems that interact with hyaluronate and derivatives injection (knee).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take hyaluronate and derivatives injection (knee) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Hyaluronate and Derivatives Injection?

• Tell all of your health care providers that you take hyaluronate and derivatives injection (knee). This includes your doctors, nurses, pharmacists, and dentists.
• Avoid activity for 48 hours or as you have been told by your doctor.
• Do not stand on your feet for more than 1 hour at a time during the first 48 hours after getting hyaluronate and derivatives injection (knee).
• Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

How is this medicine (Hyaluronate and Derivatives Injection) best taken?

Use hyaluronate and derivatives injection (knee) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• It is given as a shot.

What do I do if I miss a dose?

• Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Change in skin color where the shot was given.

What are some other side effects of Hyaluronate and Derivatives Injection?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Irritation where hyaluronate and derivatives injection (knee) is used.
• Mild pain, stiffness, or warmth in or by the knee.
• Swelling where hyaluronate and derivatives injection (knee) is used.
• Bruising.
• Back pain.
• Muscle pain.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Hyaluronate and Derivatives Injection?

• If you need to store hyaluronate and derivatives injection (knee) at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer Information Use and Disclaimer

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about hyaluronate and derivatives injection (knee), please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Frequently asked questions

• Can antidepressants be used for arthritis pain?