Benzoyl peroxide-hydrocortisone has been assigned to pregnancy category C by the FDA. Animal studies have not been reported. There are no controlled data in human pregnancy. Benzoyl peroxide-hydrocortisone topical should only be used during pregnancy when benefit outweighs risk.

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There are no data on the excretion of benzoyl peroxide-hydrocortisone topical into human milk. The manufacturer recommends caution when administering benzoyl peroxide-hydrocortisone to nursing women.

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