By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo

TheMediTary.Com

Medical Information, Documents, News - TheMediTary.Com

  • Home
  • News
  • Drugs
  • Drugs A-Z
  • Medical Answers
  • About Us
  • Contact
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo
Search Drugs
  • Drugs
    • Latest Drugs
    • Drugs A-Z
    • Medical Answers
  • News
    • FDA Alerts
    • Medical News
    • Health
    • Consumer Updates
    • Children's Health
  • More TheMediTary.Com
    • About Us
    • Contact
Follow US
Home > Drugs > Antidiabetic combinations > Glyburide and metformin > Glyburide and metformin Pregnancy and Breastfeeding Warnings
Antidiabetic combinations

Glyburide / metformin Pregnancy and Breastfeeding Warnings

Contents
Glyburide and metformin Pregnancy Warnings Glyburide and metformin Breastfeeding Warnings

Glyburide and metformin Pregnancy Warnings

Use is not recommended unless clearly needed.

AU TGA pregnancy category: C
US FDA pregnancy category: B

Comments:
-Insulin is recommended during pregnancy to maintain blood glucose levels as normal as possible.
-If this drug is used during pregnancy, it should be discontinued at least 2 weeks before the expected delivery date.

Abnormal blood glucose levels during pregnancy are associated with a higher incidence of congenital abnormalities. Reproductive studies in rats and rabbits at doses up to 500 times the human glyburide dose have not revealed evidence of harm to the fetus. Neonates born to mothers receiving a sulfonylurea at the time of delivery have experienced prolonged severe hypoglycemia, especially with use of agents that have prolonged half-lives. Sulfonylureas may not be suitable for the treatment of diabetes during pregnancy as significant metabolic changes occurring during this time make control of blood sugar difficult. Metformin itself was not teratogenic in rats or rabbits at doses up to 600 mg/kg/day. There are no adequate and well-controlled studies in pregnant women.

In the US, glyburide has been used in women with gestational diabetes. A retrospective cohort study looking at employer-based insurance claims suggests newborns born to mothers receiving glyburide were more likely to experience adverse reactions than those born to mothers receiving insulin. Of the 110,879 women identified with gestational diabetes mellitus, 4982 women were treated with glyburide and 4191 received insulin. Newborns of mothers treated with glyburide were at an increased risk for neonatal intensive care unit admission, respiratory distress, hypoglycemia, birth injury, and large for gestational age. They were not at increased risk for obstetric trauma, preterm birth, or jaundice; the risk of cesarean delivery was 3% lower. Additional studies are needed to fully assess the risks of this drug during pregnancy.

AU TGA pregnancy category C: Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible. Accompanying texts should be consulted for further details.

US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

See references

Glyburide and metformin Breastfeeding Warnings

Both glyburide and metformin are found in low levels in human milk. In a small (n=8) single-dose study, maximum estimated glyburide doses expected in fully breastfed infants would be less than 1.5% and less than 0.7% of the maternal weight-adjusted dose for the 5 and 10 mg doses, respectively. Metformin drug levels are expected to be 0.5% of their mother's weight-adjusted dosage and are expected to be relatively constant. A large study in mothers receiving metformin found no adverse effects in their breastfed infants; there were low detectable serum levels in some infants. Monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with hypoglycemic agents.

Use is not recommended and a decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.

Excreted into human milk: Yes (glyburide); Yes (metformin)

Comments: If diet alone is inadequate for controlling blood glucose, insulin therapy should be considered.

See references

Share this Article
Latest News
Medical News

Obesity, unhealthy lifestyles may cause heart to age by 5–45 years

May 08, 2025
Aging: As little as 5 minutes of exercise may keep the brain healthy
Prostate cancer: Simple urine test may help with early detection
Cancer treatment side effects: Exercise may reduce pain, fatigue
Alzheimer's: Exercising in middle age may reduce beta-amyloid in brain...
Heart disease: Just 3 minutes of 'incidental activity' may lower...
Related Drugs
Fidanacogene Elaparvovec
Cerave Anti-Itch
Centrum Adult
Crovalimab
Cyltezo Prefilled Syringe
Zepbound Pen
Mylanta One
Uretron Ds
Medihoney Wound And Burn Dressing
Lidotrode

Other drugs

Name Drug Class Updated
Fidanacogene Elaparvovec Drugs 03-Oct-2024
Cerave Anti-Itch Drugs 02-Oct-2024
Centrum Adult Drugs 02-Oct-2024
Crovalimab Drugs 02-Oct-2024
Cyltezo Prefilled Syringe Drugs 01-Oct-2024
Zepbound Pen Drugs 30-Sep-2024
Mylanta One Drugs 27-Sep-2024
Uretron Ds Drugs 27-Sep-2024
Medihoney Wound And Burn Dressing Drugs 26-Sep-2024
Lidotrode Drugs 26-Sep-2024
Libervant Drugs 26-Sep-2024
Moderna Covid-19 Drugs 25-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024

Categories

  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health

About US

Welcome to TheMediTary.Com

Our website provides reliable and up-to-date information on various medical topics. We empower individuals to take charge of their health by simplifying complex medical jargon and providing practical tips and advice. We prioritize the privacy and confidentiality of our users and welcome feedback to improve our services.

Website use data of FDA and other sources

DMCA.com Protection Status Truste Protection Status Trust Mark Protection Status
HONcode logo We comply with the HONcode standard for trustworthy health information.
Quick Link
  • About Us
  • Contact Us
  • Editorial Policy
  • Privacy Policy
  • Accessibility Policy
  • Terms & Conditions
  • Disclaimer
  • DMCA
  • Do Not Sell My Personal Information
  • Sitemap
  • Care Notes
  • Health Guide
  • Professional
Drugs
  • New Drugs
  • Medical Answers
  • Drugs A-Z
  • Drug Classes
  • Drug Dosage
  • Pill Identifier
  • Consumer Infor
  • Side Effects
  • Inactive Ingredients
  • Pregnancy Warnings
  • Patient Tips
  • Treatments
News
  • Latest News
  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health
Find US
  • Medium
  • Google Site
  • Blogspot
  • API
  • Reddit
  • Tumblr
  • Scoop.it
  • Substack
  • Wordpress
  • Wix
  • Behance

© 2025 TheMediTary.Com All rights reserved. Operated by