Note: This document contains side effect information about collagenase topical. Some dosage forms listed on this page may not apply to the brand name Santyl.
Applies to collagenase topical: topical application ointment.
Serious side effects of Santyl
Along with its needed effects, collagenase topical (the active ingredient contained in Santyl) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking collagenase topical:
Incidence not known
- Chest tightness
- difficulty with swallowing
- dizziness
- fast heartbeat
- fever
- hives, itching, skin rash
- hoarseness
- irritation
- joint pain, stiffness, or swelling
- redness of the skin
- swelling of the eyelids, face, lips, hands, or feet
- trouble breathing
Other side effects of Santyl
Some side effects of collagenase topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- Redness around the wound area
For Healthcare Professionals
Applies to collagenase topical: compounding powder, topical ointment.
General
The most commonly reported side effect was erythema.[Ref]
Hypersensitivity
Frequency not reported: Systemic manifestations of hypersensitivity (in a patient treated for more than one year with a combination of collagenase and cortisone)[Ref]
Dermatologic
Frequency not reported: Erythema[Ref]
