Note: This document contains side effect information about pegfilgrastim. Some dosage forms listed on this page may not apply to the brand name Stimufend.
Applies to pegfilgrastim: subcutaneous solution.
Serious side effects of Stimufend
Along with its needed effects, pegfilgrastim (the active ingredient contained in Stimufend) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking pegfilgrastim:
Rare
- Chills
- cough
- eye pain
- fever
- general feeling of illness
- headache
- sore throat
- unusual tiredness
Incidence not known
- Back pain
- black, tarry stools
- bleeding gums
- bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
- bloody or cloudy urine
- blue lips, fingernails, or skin
- chest pain
- decrease or increase in the amount of urine
- difficult or fast breathing
- dry, red, hot, or irritated skin
- fainting or lightheadedness
- fast heartbeat
- feeling of fullness
- fever sores or blisters on the skin
- hives, itching, skin rash
- hoarseness
- irritation
- joint pain, stiffness, or swelling
- lower back or side pain
- nausea
- painful or difficult urination
- pain spreading to the left shoulder
- pinpoint red spots on the skin
- redness of the skin
- sores, ulcers, or white spots on the lips or in the mouth
- stomach pain
- swelling of the eyelids, face, lips, hands, or feet
- swollen glands
- trouble breathing or swallowing
- unusual bleeding or bruising
- weight gain
Get emergency help immediately if any of the following symptoms of overdose occur while taking pegfilgrastim:
Symptoms of overdose
- Bone pain
- chest pain or tightness
- difficult or labored breathing
- swelling
Other side effects of Stimufend
Some side effects of pegfilgrastim may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Bone, arm, or leg pain
For Healthcare Professionals
Applies to pegfilgrastim: subcutaneous solution.
General
The most commonly reported side effects included bone pain, skeletal pain, medullary bone pain, and spontaneously reversible mild to moderate lactate dehydrogenase elevations.[Ref]
Musculoskeletal
Very common (10% or more): Bone pain (up to 31%), skeletal pain (up to 27%), medullary bone pain (up to 26%)
Common (1% to 10%): Arthralgia, back pain, extremity pain, limb pain, musculoskeletal pain, myalgia, neck pain, polyarthralgia, polymyalgia[Ref]
Metabolic
Very common (10% or more): Spontaneously reversible mild to moderate lactate dehydrogenase elevations (up to 18%), spontaneously reversible mild to moderate alkaline phosphatase elevations (up to 11%), spontaneously reversible mild to moderate uric acid elevations (up to 11%)
Common (1% to 10%): Spontaneously reversible severe uric acid elevations
Frequency not reported: Anorexia[Ref]
Other
Common (1% to 10%): Fever, non-cardiac chest pain, pain, pyrexia
Frequency not reported: Fatigue, generalized weakness, mucositis[Ref]
Dermatologic
Common (1% to 10%): Alopecia, contact dermatitis
Uncommon (0.1% to 1%): Acute febrile dermatosis, cutaneous vasculitis, erythema/generalized erythema, pruritus, skin rash, Sweet's syndrome, urticaria[Ref]
Hematologic
Common (1% to 10%): Leukocytosis, thrombocytopenia
Uncommon (0.1% to 1%): Asymptomatic splenomegaly, fatal splenic rupture, sickle cell crisis, splenic rupture, splenomegaly/enlarged spleen
Frequency not reported: Granulocytopenia, neutropenic fever[Ref]
Local
Common (1% to 10%): Application site reactions, injection site pain
Uncommon (0.1% to 1%): Injection site erythema, injection site reactions
Postmarketing reports: Application site bruise, application site discomfort, application site hemorrhage, local skin reactions[Ref]
Gastrointestinal
Common (1 to 10%): Diarrhea, nausea
Frequency not reported: Abdominal pain, constipation, dyspepsia, stomatitis, vomiting[Ref]
Immunologic
Common (1% to 10%): Influenza, preexisting binding antibodies[Ref]
Cardiovascular
Common (1% to 10%): Chest pain
Uncommon (0.1% to 1%): Capillary leak syndrome, flushing, hypotension
Rare (0.01% to 0.1%): Aortitis
Frequency not reported: Peripheral edema[Ref]
Nervous system
Common (1% to 10%): Headache
Frequency not reported: Dizziness, taste perversion[Ref]
Ocular
Common (1% to 10%): Periorbital edema[Ref]
Respiratory
Uncommon (0.1% to 1%): Acute respiratory distress syndrome (ARDS), dyspnea, fatal ARDS, interstitial pneumonia, pulmonary adverse reactions, pulmonary edema, pulmonary fibrosis, pulmonary infiltrates, respiratory failure[Ref]
Hypersensitivity
Uncommon (0.1% to 1%): Anaphylaxis, angioedema, hypersensitivity reactions/hypersensitivity-type reactions, serious allergic reactions
Frequency not reported: Allergies to acrylics
Postmarketing reports: Allergic reactions, allergic-type reactions, anaphylactic reactions[Ref]
Hepatic
Uncommon (0.1% to 1%): Transient elevations in ALT, transient elevations in AST, transient elevations in liver function tests[Ref]
Renal
Uncommon (0.1% to 1%): Glomerulonephritis[Ref]
Oncologic
Frequency not reported: Potential for tumor growth stimulatory effects on malignant cells[Ref]
Psychiatric
Frequency not reported: Insomnia[Ref]