Note: This document contains side effect information about fostamatinib. Some dosage forms listed on this page may not apply to the brand name Tavalisse.
Applies to fostamatinib: oral tablet.
Warning
Fostamatinib can raise your blood pressure, sometimes to dangerous levels. Fostamatinib may also cause liver problems, severe diarrhea, and infections.
Call your doctor if you have: headaches, chest pain, shortness of breath, severe diarrhea, stomach pain, fever, or sore throat.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
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severe diarrhea;
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stomach pain (upper right side);
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dark urine, jaundice (yellowing of the skin or eyes);
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headaches, chest pain, shortness of breath; or
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fever, sore throat, or other signs of infection.
Your fostamatinib (the active ingredient contained in Tavalisse) doses may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
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increased blood pressure;
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diarrhea, nausea, stomach pain;
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abnormal liver function tests;
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chest pain;
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dizziness, tiredness;
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rash; or
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cold symptoms such as stuffy nose, sneezing, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to fostamatinib: oral tablet.
Hematologic
Common (1% to 10%): Neutropenia[Ref]
Hepatic
Very common (10% or more): ALT increased (11%)
Common (1% to 10%): AST increased[Ref]
Respiratory
Very common (10% or more): Respiratory infection (11%)[Ref]
Other
Common (1% to 10%): Fatigue[Ref]
Nervous system
Very common (10% or more): Dizziness (11%)[Ref]
Cardiovascular
Very common (10% or more): Hypertension (28%)[Ref]
Dermatologic
Common (1% to 10%): Rash (e.g., rash erythematous, rash macular)[Ref]
Gastrointestinal
Very common (10% or more): Diarrhea (31%), nausea (19%)
Common (1% to 10%): Abdominal pain[Ref]
