Note: This document contains side effect information about trimethobenzamide. Some dosage forms listed on this page may not apply to the brand name Tigan.

Applies to trimethobenzamide: oral capsule. Other dosage forms:

• intramuscular solution

Serious side effects of Tigan

Along with its needed effects, trimethobenzamide (the active ingredient contained in Tigan) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking trimethobenzamide:

Incidence not known

• Abdominal or stomach pain
• change in consciousness
• chills
• clay-colored stools
• confusion about identity, place, and time
• dark urine
• difficulty swallowing
• discouragement
• dizziness
• feeling sad or empty
• fever
• headache
• irritability
• itching
• lack of appetite
• loss of balance control
• loss of consciousness
• loss of interest or pleasure
• mask-like face
• nausea
• pale skin
• rash
• seizures
• severe spasm where the head and heels are bent backward and the body arched forward
• shuffling walk
• slowed movements of the arms and legs
• slurred speech
• sore throat
• swelling of the arms, face, legs, lips, tongue, or throat
• tic-like (jerky) movements of the head, face, mouth, and neck
• trembling and shaking of the fingers and hands
• trouble concentrating
• trouble sleeping
• unpleasant breath odor
• unusual bruising or bleeding
• unusual tiredness or weakness
• vomiting of blood
• yellow eyes or skin

Other side effects of Tigan

Some side effects of trimethobenzamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Blurred vision
• diarrhea
• drowsiness
• muscle cramps

For Healthcare Professionals

Applies to trimethobenzamide: compounding powder, intramuscular solution, oral capsule, rectal suppository.

Nervous system

Frequency not reported: Coma, convulsions, disorientation, dizziness, drowsiness, headache, opisthotonos, Parkinson-like/extrapyramidal symptoms^[Ref]

Hypersensitivity

Frequency not reported: Allergic-type skin reactions, angioedema, hypersensitivity reactions^[Ref]

Cardiovascular

Frequency not reported: Hypotension^[Ref]

Psychiatric

Frequency not reported: Depression^[Ref]

Gastrointestinal

Frequency not reported: Diarrhea^[Ref]

Hepatic

Frequency not reported: Jaundice^[Ref]

Musculoskeletal

Frequency not reported: Muscle cramps^[Ref]

Hematologic

Frequency not reported: Blood dyscrasias^[Ref]

Ocular

Frequency not reported: Blurred vision^[Ref]