Note: This document contains side effect information about telotristat. Some dosage forms listed on this page may not apply to the brand name Xermelo.
Summary
Common side effects of Xermelo include: constipation. Continue reading for a comprehensive list of adverse effects.
Applies to telotristat: oral tablet.
Serious side effects of Xermelo
Along with its needed effects, telotristat (the active ingredient contained in Xermelo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking telotristat:
Incidence not known
- Severe constipation
- severe stomach pain
Other side effects of Xermelo
Some side effects of telotristat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- decreased appetite
- discouragement
- excess air or gas in the stomach or intestines
- feeling sad or empty
- fever
- full feeling
- headache
- irritability
- lack of appetite
- loss of interest or pleasure
- nausea
- passing gas
- rapid weight gain
- tingling of the hands or feet
- tiredness
- trouble concentrating
- trouble sleeping
- unusual weight gain or loss
For Healthcare Professionals
Applies to telotristat: oral tablet.
General
The most commonly reported side effects included abdominal pain, increased GGT, nausea, and/or headaches.[Ref]
Gastrointestinal
Very common (10% or more): Abdominal pain (up to 26%), nausea (up to 13%)
Common (1% to 10%): Abdominal distention, constipation, flatulence
Frequency not reported: Gastrointestinal pain, lower abdominal pain, serious constipation, upper abdominal pain[Ref]
Hepatic
Very common (10% or more): Increased GGT (up to 11%)
Common (1% to 10%): ALT increased, AST increased, blood alkaline phosphatase increased
Frequency not reported: GGT, liver enzymes increased, liver function test abnormal[Ref]
Nervous system
Very common (10% or more): Headache (up to 11%)[Ref]
Psychiatric
Common (1% to 10%): Depressed mood, depression
Frequency not reported: Decreased interest[Ref]
Other
Common (1% to 10%): Fatigue, pyrexia[Ref]
Cardiovascular
Common (1% to 10%): Peripheral edema[Ref]
Metabolic
Common (1% to 10%): Decreased appetite[Ref]
