Miscellaneous metabolic agents
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Amvuttra Dosage

Drug Detail:Amvuttra (Vutrisiran)

Generic Name: VUTRISIRAN 25mg in 0.5mL

Dosage Form: injection

Drug Class: Miscellaneous metabolic agents

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

Recommended Dosage

The recommended dosage of AMVUTTRA is 25 mg administered by subcutaneous injection once every 3 months [see Dosage and Administration (2.2)].

Missed Dose

If a dose is missed, administer AMVUTTRA as soon as possible. Resume dosing every 3 months from the most recently administered dose.

Administration Instructions

AMVUTTRA is for subcutaneous use only and should be administered by a healthcare professional.

Syringe Appearance Before and After Use

Before UseImage After UseImage

Preparation and Administration

1.
Prepare the syringe
If stored cold, allow the syringe to warm to room temperature for 30 minutes prior to use.
Remove the syringe from the packaging by gripping the syringe body.
Do not touch the plunger rod until ready to inject.
Visually inspect the drug solution for discoloration and particulate matter prior to administration. AMVUTTRA is a sterile, preservative-free, clear, colorless-to-yellow solution. Do not use if it contains particulate matter or if it is cloudy or discolored.
Check the following:
  • Syringe is not damaged, such as cracked or leaking
  • Needle cap is attached to the syringe
  • Expiration date on syringe label
Do not use the syringe if any issues are found while checking the syringe.
2.
Choose and prepare the injection site
Choose an injection site from the following areas: the abdomen, thighs, or upper arms.
Avoid the following:
  • 5-cm area around the navel
  • Scar tissue or areas that are reddened, inflamed, or swollen
Clean the chosen injection site.
 Image
3.
Prepare the syringe for injection
Hold the syringe body with one hand. Pull the needle cap straight off with other hand and dispose of needle cap immediately. It is normal to see a drop of liquid at the tip of the needle.
Do not touch the needle or let it touch any surface.
Do not recap the syringe.
Do not use the syringe if it is dropped.
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4.
Perform the injection
Pinch the cleaned skin.
Fully insert the needle into the pinched skin at a 45°-90° angle.
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Inject all of the medication.
Push the plunger rod as far as it will go to administer the dose and activate the needle shield.
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Release the plunger rod to allow the needle shield to cover the needle.
Do not block plunger rod movement.
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5.
Dispose of the syringe
Immediately dispose of the used syringe into a sharps container.
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