Usual Adult Dose for Methotrexate Overdosage

Single IV injection of 50 Units/kg

Use: Treatment of toxic plasma methotrexate concentrations (greater than 1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function.

Usual Pediatric Dose for Methotrexate Overdosage

Children 1 month of age or older: Single IV injection of 50 units/kg

Use: Treatment of toxic plasma methotrexate concentrations ( greater than 1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 1 month of age.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available.

Other Comments

Administration advice:

• Administer intravenously as a bolus injection over 5 minutes.
• Flush intravenous line before and after administration.