Drug Detail:Glucarpidase (Glucarpidase [ gloo-kar-pi-dase ])
Drug Class: Antidotes
Usual Adult Dose for Methotrexate Overdosage
Single IV injection of 50 Units/kg
Use: Treatment of toxic plasma methotrexate concentrations (greater than 1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function.
Usual Pediatric Dose for Methotrexate Overdosage
Children 1 month of age or older: Single IV injection of 50 units/kg
Use: Treatment of toxic plasma methotrexate concentrations ( greater than 1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function.
Renal Dose Adjustments
No adjustment recommended
Liver Dose Adjustments
Data not available
Precautions
CONTRAINDICATIONS: None
Safety and efficacy have not been established in patients younger than 1 month of age.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available.
Other Comments
Administration advice:
- Administer intravenously as a bolus injection over 5 minutes.
- Flush intravenous line before and after administration.
Storage requirements: Store at 36F to 46F (2C to 8C)
Reconstitution/preparation techniques: The manufacturer product information should be consulted.
General: Do not freeze