Note: This document contains side effect information about estramustine. Some dosage forms listed on this page may not apply to the brand name Emcyt.
Applies to estramustine: oral capsule.
Serious side effects of Emcyt
Along with its needed effects, estramustine (the active ingredient contained in Emcyt) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking estramustine:
Rare
- Black, tarry stools
- blood in urine or stools
- cough or hoarseness
- fever or chills
- headaches (severe or sudden)
- loss of coordination (sudden)
- lower back or side pain
- painful or difficult urination
- pains in chest, groin, or leg (especially calf of leg)
- pinpoint red spots on skin
- shortness of breath (sudden, for no apparent reason)
- slurred speech (sudden)
- unusual bleeding or bruising
- vision changes (sudden)
- weakness or numbness in arm or leg
Check with your doctor as soon as possible if any of the following side effects occur while taking estramustine:
More common
- Swelling of feet or lower legs
Rare
- Skin rash or fever
- unusual tiredness or weakness
Other side effects of Emcyt
Some side effects of estramustine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Breast tenderness or enlargement
- decreased interest in sex
- diarrhea
- nausea
Less common
- Trouble in sleeping
- vomiting
For Healthcare Professionals
Applies to estramustine: oral capsule.
Endocrine
Very common (10% or more): Breast tenderness (66%), breast enlargement (60%), gynecomastia
Frequency not reported: Erectile dysfunction[Ref]
Hepatic
Very common (10% or more): Abnormal LDH and/or AST (31%), abnormal hepatic function
Common (1% to 10%): Abnormal bilirubin[Ref]
Other
Very common (10% or more): Edema (19%)
Common (1% to 10%): Chest pain
Frequency not reported: Injection site thrombosis[Ref]
Gastrointestinal
Very common (10% or more): Nausea (15%), diarrhea (12%), minor gastrointestinal upset (11%), vomiting
Common (1% to 10%): Flatulence, gastrointestinal bleeding[Ref]
Respiratory
Very common (10% or more): Dyspnea (11%)
Common (1% to 10%): Pulmonary emboli, upper respiratory discharge, hoarseness, burning throat
Frequency not reported: Larynx edema[Ref]
Cardiovascular
Very common (10% or more): Congestive heart failure
Common (1% to 10%): Myocardial infarction, thrombophlebitis
Frequency not reported: Myocardial ischemia, hypertension[Ref]
Hematologic
Very common (10% or more): Anemia, leukopenia
Common (1% to 10%): Thrombocytopenia[Ref]
Metabolic
Very common (10% or more): Fluid retention
Common (1% to 10%): Anorexia, thirst[Ref]
Dermatologic
Common (1% to 10%): Pruritus, dry skin, rash, easy bruising, flushing, peeling skin on fingertip, thinning hair[Ref]
Musculoskeletal
Common (1% to 10%): Leg cramps
Frequency not reported: Muscular weakness[Ref]
Nervous system
Common (1% to 10%): Lethargy, cerebrovascular accident, headache[Ref]
Ocular
Common (1% to 10%): Tearing of eyes[Ref]
Psychiatric
Common (1% to 10%): Insomnia, emotional lability, anxiety
Frequency not reported: Confusional state, depression[Ref]
Hypersensitivity
Frequency not reported: Hypersensitivity reactions, allergic reactions, angioedema, allergic dermatitis[Ref]