Uses of Eflornithine:

• It is used to lower the growth of unwanted facial hair in females.
• It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Eflornithine?

For all patients taking eflornithine:

• If you have an allergy to eflornithine or any other part of eflornithine.
• If you are allergic to eflornithine; any part of eflornithine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

Children:

• If your child is younger than 12 years of age. Do not give eflornithine to a child younger than 12 years of age.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take eflornithine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Eflornithine?

• Tell all of your health care providers that you take eflornithine. This includes your doctors, nurses, pharmacists, and dentists.
• You will still need to remove hair other ways while using eflornithine.
• It may take several weeks to see the full effects.
• Talk with your doctor before you use other drugs or products on your skin.
• After stopping treatment, the hair will go back to how it was before treatment.
• Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using eflornithine while you are pregnant.
• Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Eflornithine) best taken?

Use eflornithine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Do not take eflornithine by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
• Wash your hands before and after use.
• Use at least 5 minutes after you get rid of hair.
• Put a thin layer on the affected skin and rub in gently.
• Do not wash affected part for at least 4 hours.
• Makeup may be used after the skin has dried.

What do I do if I miss a dose?

• Skip the missed dose and go back to your normal time.
• Do not put on 2 doses or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Very bad skin irritation.

What are some other side effects of Eflornithine?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Pimples (acne).
• Burning.
• Stinging.
• Hair bumps.
• Skin irritation.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Eflornithine?

• Store at room temperature. Do not freeze.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer Information Use and Disclaimer

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about eflornithine, please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.